The Frostbite Effect

The Frostbite Effect is a state of corruption inflicted on one who uses a light prism's powers for the pure evil and their selfishness. This effect can only affect mortals and organic life, for example, Bowser. It mainly affects one's intelligence and state of thinking. As power from the prism is deceased, more skin or flesh will become white and emit white light.

Cause
If a mortal or organic entity uses a light prism as a personal gain for universe domination and/or indestructible power, it can deal serious damage to both the body and every universe to exist. As the prism is one of the most powerful entity and is an embodiment of light itself, it has the capability of collapsing under extreme pressure and careless manipulation and destroying both itself and everything to exist. When a prism is finally fully manipulated, it would have no choice but to answer to anyone, more specifically, Bowser.

When the prism is used for the wrong reasons, as Bowser did, it can have a huge impact on how one thinks. Stripping them from common sense and sympathy for others, mainly family members. A prime example of this is in the final episode of Worlds Collide, 'The End of a Chapter', when Bowser demanded the prism to kill the WC's including Junior, showing no care and completely forgetting about how to show affection. Note that this wasn't in all Bowser's intent, as his mind was corrupted from the effect, but he still wanted to kill the rest of the WC's.